Search on:
11BETA HYDROXYSTEROID DEHYDROGENASE TYPE 2
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
11-beta-Hydroxysteroid Dehydrogenase Type 2
Descriptor
Spanish
:
11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 2
Descriptor
Portuguese
:
11-beta-Hidroxiesteroide Desidrogenase Tipo 2
Synonyms
English
:
11 beta Hydroxysteroid Dehydrogenase Type 2
11 beta-HSD2
11 beta-Hydroxysteroid Dehydrogenase Type 2
11beta Hydroxysteroid Dehydrogenase Type 2
11beta-HSD2
11beta-HSD2 Reductase
11beta-Hydroxysteroid Dehydrogenase Type 2
Tree Number:
D08.811.682.047.436.174.600
D08.811.682.047.820.100.600
Definition
English
:
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to
CORTISONE
. It is found predominantly in mineralocorticoid target
tissues
such as the
KIDNEY
; COLON;
SWEAT GLANDS
; and the
PLACENTA
. Absence of the enzyme leads to a fatal form of childhood
hypertension
termed,
APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Entry Combination - descr/qualif
English
:
11-beta-Hydroxysteroid Dehydrogenase Type 2
/
deficiency
use
Mineralocorticoid Excess Syndrome, Apparent
History Note
English
:
2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
38200
Unique Identifier:
D043209
Occurrence in VHL
:
Similar:
DeCS